Peptide Mediated Antimicrobial Dental Adhesive System

Modifications of Dental Adhesive Systems

Adhesion is the procedure of forming an adhesive joint. The initial substrate is termed adherend and the material producing the interface is termed the adhesive [1]. The functions of dental adhesives is to promote conservation of tooth structure and enable minimally invasive dentistry, reinforcement of weakened dentin or enamel, reduce marginal staining, reduce microleakag and may also reduce p...

Human antimicrobial peptide LL-37 induces glial-mediated neuroinflammation.

LL-37 is the sole cathelicidin-derived antimicrobial peptide found in humans. It becomes active upon C-terminal cleavage of its inactive precursor hCAP18. In addition to antimicrobial action, it also functions as an innate immune system stimulant in many tissues of the body. Here we report that hCAP18 and LL-37 are expressed in all organs of the human body that were studied with the highest bas...

Diminished Antimicrobial Peptide and Antifungal Antibiotic Activities against Candida albicans in Denture Adhesive

The underlying causes of denture stomatitis may be related to the long-term use of adhesives, which may predispose individuals to oral candidiasis. In this study, we hypothesize that antimicrobial peptides and antifungal antibiotics have diminished anti-Candida activities in denture adhesive. To show this, nine antimicrobial peptides and five antifungal antibiotics with and without 1.0% denture...

Cathelicidin Antimicrobial Peptide Activity Is Mediated by Expression of Cutting Edge: Mast Cell Antimicrobial

Amelogenin exons 8 and 9 encoded peptide enhances leucine rich amelogenin peptide mediated dental pulp repair.

Amelogenins containing exons 8 and 9 are alternatively spliced variants of amelogenin. Some amelogenin spliced variants have been found to promote pulp regeneration following pulp exposure. The function of the amelogenin spliced variants with the exons 8 and 9 remains unknown. In this study, we synthesized recombinant leucine rich amelogenin peptide (LRAP, A-4), LRAP plus exons 8 and 9 peptide ...